Nomark Gel

✔️ Uses of Nomark Gel

• Treatment of Acne

✔️ How does Nomark Gel work?

Adapalene, a topical retinoid, regulates the skin cell cycle and prevents the accumulation of excess sebum and dead skin cells on hair follicles. This action reduces inflammation in the skin.

Benzoyl peroxide, a keratolytic agent with antimicrobial properties, enhances the natural exfoliation of dead skin cells. It also reduces the population of acne-causing bacteria on the skin, thereby preventing the further spread of acne.

Together, these ingredients unclog hair follicles and exfoliate dead skin cells, effectively reducing acne breakouts.

✔️ Side Effects of Nomark Gel

• Dry skin
• Skin redness and scaling
• Burning sensation of the skin
• Skin irritation

✔️ Quick Tips:

• Always use Adapalene + Benzoyl peroxide exactly as prescribed by your healthcare provider. Do not use more or less than instructed
• Before applying any medications to your entire face, consider doing a patch test on a small area of your skin to check for any adverse reactions or allergies
• Let the medicine completely dry on your skin before applying any makeup products or cosmetics. Avoid contact of Adapalene + Benzoyl peroxide with eyes, ears, mouth, or vagina
• Both Adapalene and Benzoyl peroxide can make your skin more sensitive to the sun. Therefore, use a broad-spectrum sunscreen every morning, even on cloudy days. This helps prevent sunburn and further skin damage
• While using these medications, avoid using other harsh skincare products that might further irritate your skin, such as products containing alcohol, strong exfoliants, or astringents
• Drinking plenty of water and maintaining a balanced diet can contribute to overall skin health

✔️ Pharmacology

Nomark 10 gel is indicated for the topical treatment of acne vulgaris in patients aged 12 years and older. Adapalene, one of its active ingredients, binds to specific retinoic acid nuclear receptors but not to cytosolic receptor proteins. Studies have shown that Adapalene modulates cellular differentiation, keratinization, and inflammatory processes. It binds to specific retinoic acid nuclear receptors, normalizing the differentiation of follicular epithelial cells and resulting in reduced microcomedone formation. Benzoyl peroxide, another active ingredient, is an oxidizing agent with bacteriocidal and keratolytic effects.

✔️ Dosage & Administration of Nomark Gel

• Here are the administration and dosage instructions for Adapalene & Benzoyl peroxide gel:
• Apply a thin film of the gel to the affected areas of the face and/or trunk once daily after washing.
• Use a pea-sized amount for each area of the face, such as the forehead, chin, and cheek.
• Avoid applying the gel near the eyes, lips, and mucous membranes.
• Do not use Adapalene & Benzoyl peroxide gel orally, in the eyes, or intravaginally.

Regarding pediatric use:

• The safety and effectiveness of Adapalene and Benzoyl peroxide gel in pediatric patients under the age of 12 years have not been established. Therefore, it is not recommended for use in children under 12 years old.

✔️ Interaction

Drug-Drug Interaction: Nomark Gel may interact with vitamin A-related drugs (retinoids), photosensitizing agents, antibiotics, sensitizers, keratolytic agents, and antiseptics. It's essential to inform your doctor if you're taking any of these medications to avoid potential interactions.

Drug-Food Interaction: No interactions with food have been reported for Nomark Gel.

Drug-Disease Interaction: Patients with eczema or sunburned skin should inform their doctor before using Nomark Gel, as it may affect their condition.

✔️ Therapeutic Category

Adapalene: Topical retinoid

Benzoyl peroxide: Keratolytic agent

✔️ Contraindications:

Hypersensitive to any of the components.

✔️ Pregnancy & Lactation

The safety of Nomark 10 gel has not been established through well-controlled trials in pregnant women. Animal reproduction studies have not been conducted with the combination gel or Benzoyl peroxide. However, it's important to note that such animal studies are not always predictive of human response. Therefore, Nomark 10 gel should only be used during pregnancy if the potential benefits justify the risk to the fetus.

It is unknown whether Adapalene or Benzoyl peroxide is excreted in human milk following use. Caution should be exercised when administered to a nursing woman. It's advisable to consult with a healthcare professional before using Nomark 10 gel during pregnancy or while breastfeeding to assess the potential risks and benefits.

✔️ Precautions & Warnings

• If you have known allergies to Nomark Gel or any other medications, inform your doctor.
• Do not apply Nomark Gel on cuts, open wounds, scrapes, sunburned, windburned, chapped, dry, or irritated skin.
• Nomark Gel is for external use only. Do not swallow it. In case of accidental swallowing, consult a doctor.
• Avoid contact with Nomark Gel with the nose, ears, mouth, or eyes. If it comes in contact with these areas accidentally, rinse with warm water thoroughly.
• Avoid exposure to tanning beds or sunlight while using Nomark Gel as it may make the skin more sensitive to sunlight and cause sunburn. Wear protective clothing and use sunscreen while going out.
• Inform your doctor if you are pregnant or breastfeeding before using Nomark Gel.
• Do not apply Nomark Gel in large amounts or use it for a longer time than prescribed, as it may increase the risk of side effects such as irritation, scaling, or redness of the skin.

Inform your doctor if you have eczema (itchy, swollen, rough, and cracked skin) or sunburned skin before using Nomark Gel.

✔️ Storage Conditions:

Protect from light and moisture by storing below 30°C. Keep the medicine out of children's reach.